Clinical Research Studies

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STUDY NAME TYPE OF STUDY
SYNOPSIS/SUMMARY DEPARTMENT PHARMACEUTICALS/OTHER STUDY START
STUDY END
(BiDiL XR) A Randomized, Open-Label, Daily Dose, Two-sequence, Two-way Crossover Pharmacodynamics and Pharmacokinetic Study of BiDil XR Capsules and Commercial BiDil Tablets in Self-identified Black Patients, who are Slow Acetylators, with Heart Failure Medicine/Cardiology PHARMACEUTICALS ARBOR  02/00/2016 06/00/2016
GRAHF II

Genomic Analysis of Enhanced Receptors to Heart Failure Therapy in African Americans

Medicine/Cardiology NATIONAL INSTITUTE OF HEALTH  05/00/2015 04/00/2019
(P4) PERSONALIZED HEALTH FOR WOMEN

A registry to study factors influencing the development and progression of Cardiovascular disease in Women throughout their life span 

Medicine/Cardiology NATIONAL INSTITUTE OF HEALTH (NIH) & NCATS  03/05/2014 03/04/2039
Paragon

Evaluate the efficacy and safety of Entresto compared to Valsartan, on morbidity and mortality in Heart Failure patients (NYHA II-IV) with preserved ejection fraction

Medicine/Cardiology NOVARTIS PHARMACEUTICALS  10/01/2014  08/21/2021
RELAX-HF

Evaluate the efficacy, safety and tolerability of SeRelaxin when added to standard therapy in acute Heart Failure patients – Harris/DOM

Medicine/Cardiology PHARMACEUTICAL- NOVARTIS  07/00/2013  07/00/2017
GALAXY

LonG term EvALuAtion LinoX FamilY ICD Lead Study

Medicine/Cardiology PHARMACEUTICAL-BIOTRINIK, INC.  06/00/2010  11/00/2016
COMMANDER-HF

A Randomized, Double-blind, Event-driven, Multicenter study comparing the Efficacy and Safety of Rivaroxaban with Placebo for Reducing the Risk of Death, Myocardial Infarction or Stroke in Subjects with Heart Failure and Significant Coronary Artery Disease Following an Episode of Decompensated Heart Failure.

Medicine/Cardiology PHARMACEUTICAL-JANSSEN  08/00/2014  09/00/2017
Veggie Dash

Comparative Effects of the DASH Diet and a Dairy-Free Vegetarian Diet on the Gut Microbiome and Blood Pressure in Obese Pre-Hypertensive African American Women at Risk for  Cardiovascular Disease

Clinical Research Center (CRC) ACADEMY OF NUTRITION AND DIETETICS FOUNDATION  01/27/2014  03/01/2017
Legume Diet Satiety and Weight Loss Pilot Study Clinical Research Center (CRC) EMORY  12/29/2014  11/16/2016
Big Grains Small Waist
 Comparative Effects of a Diet Based on USDA Guidelines for Grains and a Whole Grain Diet on Weight Loss, Body Composition, Blood Glucose, and Blood Pressure in Obese African American Women (The Big Grains Small Waist Study) Clinical Research Center (CRC) MOREHOUSE SCHOOL OF MEDICINE  06/10/2016  07/15/2017
Epilepsy Adapting Evidence-based Epilepsy Self-management Programs to Blacks in Georgia Cardiovascular Research Institure (CVRI) CENTER FOR DISEASE CONTROL  10/01/2014  08/31/2021
Second Hand Smoke Determinants and Consequences of Secondhand Smoke Exposure in African American Children Cardiovascular Research Institure (CVRI) NATIONAL INSTUTUTE on MINORITY HEALTH and DISPARITIES (NIMHD)  03/21/2012  02/28/2017
 Pancreatic Cancer
Leptin-Notch Axis in Pancreatic Cancer Surgery U54 PARTNERSHIP GRANT UAB/MSM/TUSKEGEE UNIV.  09/01/2014  08/31/2016
Sexually Transmitted Infections (STIs)  Sexual Counseling and Diagnosis of Sexually Transmitted Infections (STIs)
Family Medicine INSTITUTIONAL FUNDS  04/01/2015  04/01/2017
Postpartum Contraceptive Choice and Adherence Postpartum Contraceptive Choice and Adherence at Grady Health System Gynecology & Obstetrics   INSTITUTIONAL FUNDS  04/00/2016  04/00/2017
Sexually Transmitted Diseases (STDs) Perceptions about Sexually Transmitted Diseases (STDs) and Sexual Practices Among Post-Menopausal Women attending two inner city clinics Gynecology & Obstetrics INSTITUTIONAL FUNDS  05/01/2015  05/01/2017
SPRINT A randomized controlled clinical trial examining the effects of a high blood pressure treatment strategy aimed at reducing systolic blood pressure (SBP) to a lower goal than currently recommended.  Medicine/GIM NATIONAL HEART LUNG & BLOOD INSTITUTE  07/02/2011  06/30/2016
ASPREE A double blinded randomized, placebo-controlled primary prevention trial. The study examines whether the benefits of a low dose of Aspirin (particularly the prevention of heart disease, stroke, certain cancers and dementia) outweigh the risks in the age group of 65 years or older. Medicine/GIM NATIONAL INSTITUTE OF AGING  02/15/2012  12/31/2017
HIV/PAH The main objective of this study is to determine the prevalence of pulmonary arterial hypertension (PAH) among HIV-infected individuals in an underserved, urban, predominantly African-American population.  Medicine/Pulmonary NATIONAL INSTITUTE OF HEALTH PILOT  04/29/2014  03/24/2017
DIVA 3 Dietary Intervention to Investigate Vascular Functions in African American Women Medicine/GIM NATIONAL INSTUTUTE on MINORITY HEALTH and DISPARITIES (NIMHD)  03/01/2013
BI-1245.29 A randomized double-blind, placebo-controlled, parallel group, efficacy and safety study of empagliflozin (10mg, 25mg) administered orally, once daily over 24 weeks in hypertensive black/African American patients with type 2 diabetes mellitus Medicine/GIM PHARMACEUTICAL-BOEHRINGER INGELHEIM  11/01/2015
Credence

A Randomized, Double-blind, Event-driven, Placebo-controlled, Multicenter Study of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Subjects With Type 2 Diabetes Mellitus and Diabetic Nephropathy

Medicine/Nephrology PHARMACEUTICAL, JANSSEN RESEARCH & DEVELOPMENT, LLC  09/29/2015  03/00/2019
Sleep Study  Daily sleep deficiencies and circadian misalignment predispose shift workers to higher morbidity. Neuroscience P50 - NATIONAL HEART, LUNG AND BLOOD INSTITUTE (NHLBI)
 04/01/2015  06/30/2018
MK-3475 This is a non-randomized, multi-site, open label trial of pembrolizumab (MK3475) in subjects with multiple types of advanced rare cancers to be conducted in conformance with Good Clinical Practices. The primary purpose of this trial is to assess the Objective Response Rate to treatment with pembrolizumab  Medicine/Oncology PHARMACEUTICAL-MERCK, SHARP & DOHME INC.  09/00/2015  00/00/2020
MRSA - Pediatrics
Randomized, Double-Blind Trial of Clindamycin,Trimethoprim-Sulfamethoxazol, or Placebo for uncontrolled Skin and Soft Tissue infection caused by Community-Associated Methicillin-Resistant Staphylococcus Aureus DMID Protocol # 07-0051 (Protocol Version 6 date: 1/10/2012). Clinical Research Center (CRC) Pediatrics NATIONAL INSTITUES OF HEALTH, NATIONAL INSTITE OF ALLERGY AND INFECTIONS DISEASES
 11/01/2011 10/31/2016
MSM Total Cancer Care Protocol A Lifetime Partnership with Patients Who Have or May be at Risk of Having Cancer Surgery MOREHOUSE SCHOOL OF MEDICINE (MSM)
 03/00/2016 Indefinite
Fecal Microbiota Transplant (FMT) This study is designed to prospectively treat and follow patients with recurrent CDI who qualify for FMT under the CHOA guidelines approved by the CHOA medical executive committee in March 2014. Our goal is to demonstrate safety and efficacy of FMT using Openbiome product in children who have recurrent CDI despite at least two courses of antibiotics including a prolonged course of vancomycin. Clinical Research Center (CRC) Pediatrics  CHOA FRIEND's GRANT
 07/01/2016 06/30/2017
CDC Secretor To determine if vaccine-take of the human attenuated monovalent G1P[8] rotavirus vaccine (Rotarix, GSK, Rixensart, Belgium, Abbreviation RV1) in non-Hispanic US infants is associated with the secretor phenotype and genotype status of the infants. Clinical Research Center (CRC) Pediatrics ATLANTA RESEARCH & EDUCATION FOUNDATION (AREF)
SMASHCAP

The purpose of this proposal is to compare different connectors that are commonly used in the healthcare setting for medical procedures. These connectors are used to help with administration of intravenous lines. We will be comparing the standard luer connector to another connector, SmashCap, which was created to help reduce touch contamination. We hypothesize that the SmashCap will be less likely to have touch contamination from bacteria than standard luer connectors. This project will evaluate the acceptability of SmashCap compared to the standard luer connectors in simulated clinical settings using pediatric and adult nurses, who vary in terms of frequency of accessing intravenous (IV) lines.

Clinical Research Center (CRC) Pediatrics ATLANTA CLINICAL & TRANSLATIONAL SCIENCE INSTITUTE (ACTSI)
ED

"Surveillance of Community-Associated MRSA and Treatment Outcomes of Skin & Soft Tissue

Infections in the Ambulatory Setting"

Clinical Research Center (CRC) Pediatrics AGENCY FOR HEALTHCARE RESEARCH AND QUALITY - NATIONAL INSTITUTESO F HEALTH (NIH)  12/01/2014 11/30/2017
GIS/K08

This proposal seeks to define the contributions of socio -environmental and -economic factors to the growing epidemic of the antibiotic resistant bacterium, community acquired methicillin resistant Staphylococcus aureus (CA-MRSA).

Clinical Research Center (CRC) Pediatrics AGENCY FOR HEALTHCARE RESEARCH AND QUALITY - NATIONAL INSTITUTESO F HEALTH (NIH)  09/01/2015   08/31/2020
CATCH We will implement a health education program that includes a unique peer educator partnership between a public school system, a public housing authority, an inner-city hospital based teen health clinic, and a medical school in Atlanta, Georgia. Clinical Research Center (CRC) Pediatrics AMERICAN ACADEMY OF PEDIATRICS
 04/01/2016  03/31/2017
Microbiome The purpose of this study is to look at the differences in the bacteria that live in the gut of children of different weights to evaluate whether these gut bacteria play a role in a child’s overall health and weight. Clinical Research Center (CRC) Pediatrics INSTITUTION  07/01/2016  06/30/2017
Immune

There are currently gaps in scientific knowledge regarding why some children develop recurrent skin/soft tissue infections due to community-associated methicillin-resistant Staphylococcus aureus (MRSA) while others do not. The focus of this proposal is to observe very specific host immune factors thought to be associated with defense mechanisms against S. aureus and to concurrently look for virulent factors which are strain specific.

Clinical Research Center (CRC) Pediatrics ATLANTA CLINICAL & TRANSLATIONAL SCIENCE INSTITUTE (ACTSI)/NATIONAL INSTITUTE OF HEALTH (NIH)
 12/01/2014 11/30/2017
Shift Workers Using an innovative methodology developed and validated by our laboratory, we propose to establish proof-of-concept that shift workers from the local community exhibit stronger immunological responses to bacterial products than do day workers using our novel assay for Aberrant Inflammatory Responses (AIR). Clinical Research Center (CRC) Pediatrics  ATLANTA CLINICAL & TRANSLATIONAL SCIENCE INSTITUTE (ACTSI)/NATIONAL INSTITUTE OF HEALTH (NIH)  07/01/2016  06/30/2017